Yashica Pharmaceuticals
Yashica Pharmaceuticals
Yashica Pharmaceuticals

Yashica Pharmaceuticals


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Dimercaprol Injections

Our company has created niche in the medical industry, by offering well-formulated range of Yashicaprol injection (dimercaprol). It maintains the accurate ph value and ensures precise composition. It is a chelating agent and removes the metal poisoning from the blood. It inhibits the reaction of metallic poison that may be gold, arsenic or any other harmful metal and gets secreted in the kidneys. We offer injection with 50 mg strength capacity and should be consumed under the expert supervision of doctors as its overdose or exceeding measurable quality can cause adverse health problems to the patients.

  • Each mL contains: dimercaprol USP: 50 mg, benzyl benzoate USP: 9.6% v/v, peanut oil USP: q s
  • Chelating agent for use in heavy metal poisoning
Method of action:
  • Dimercaprol chelates heavy metals e.g. arsenic, gold, mercury, lead as well as bismuth, nickel and thallium by competing with endogenous sulfhydryl groups on enzymes. This chelation prevents or reverses any inhibition of sulfhydryl enzymes by the metallic poison and forms a complex readily secreted in the kidneys. The chemical gets readily dissolved in the body including the brain cells.
  • Absorption: peak plasma concentration after 30 to 60 min (IM)
  • Distribution: to all tissues including the brain
  • Metabolism: rapidly hepatic, converted to inactive metabolites.
  • Excretion: urine and bile (as metabolites and dimercaprol-metal chelates); 4 hours (elimination half-life).
Indication and usage:
  • Dimercaprol Injections is indicated in the treatment of acute poisoning by certain heavy metals, arsenic, gold, bismuth, antimony and possibly thallium. Although dimercaprol has not been successful in the treatment of lead poisoning when used alone, there is evidence that used in conjunction with sodium calcium edentate; it can be used successfully in the treatment of lead poisoning, particularly in children.
Dosage & administration:
  • Children: Dimercaprol Injections is well tolerated by children and the dosage should be calculated on the basis of bodyweight, using the same unit dose per Kg body weight as for an adult under similar clinical circumstances.
  • Adults: 400 to 800 mg, in divided doses, on the first day; 200 to 400 mg, in divided doses, on the second and third day; 100 to 200 mg, in divided doses, on the subsequent days. Within the above dose range, individual dosage should be calculated on a bodyweight basis and will depend upon the sensitivity of symptoms and the causative agent. As a general guide, single doses should not be exceeded 3 mg/kg bodyweight. However, in severe acute poisoning, single doses up to 5 mg per kg bodyweight may be required initially.
  • Elderly: there is no specific data on the use of dimercaprol in the elderly but since it is eliminated via the kidney, it should be used with caution in the aged group.
  • Iron, selenium, cadmium and organic mercury poisoning, hypersensitivity, extensive hepatic failure, lactation
Adverse effect:
  • Hypertension, tachycardia, malaise, salvation, lacrimation, sweating, tingling of extremities, local pain and abscess at injection site, CNS stimulation, nausea, vomiting, burning sensation of lips, mouth, throat and eyes, muscle and abdominal pain, headache, paraesthesia, fever.
Potentially fatal:
  • Potentiation of toxicity of iron, selenium, telluriun, cadmium, exacerbation of hypertension, hemolytic crisis in patients with G6PD deficiency.
Special precautions:
  • Renal damage, hypertension, G6PD deficiency, elderly, pregnancy and lactation
Drug interactions:
  • Drugs which acidify urine may impair the estimation of chelated dimercaprol.
  • Potentially fatal: Forms toxic complexes with iron, cadmium, selenium or uranium
  • Store between temperatures 20℃ to 25℃. Protect from light.
  • Keep out of reach of children.
  • 2 ampoules of 2 mL in a plastic tray and each tray packed in a printed carton.

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