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Yashica Pharmaceuticals
Yashica Pharmaceuticals
Yashica Pharmaceuticals

Yashica Pharmaceuticals

Yashica

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Veterinary Formulations

We are the manufacturer of reliable Veterinary Formulations that are meant for the treatment of various animal diseases. The medical formulation feature longer shelf life and effective curing capability with faster relief. The formulations are prescribed by various veterinary practitioners for different ailments in cats and dogs.

Fipronil Spray (0.25% w/v 100 mL)

The Fipronil spray is used for effective treatment and prevention of all life stages of ectoparasites in cats and dogs. The spray poses no harmful effect on the fur of animals. It stays on for longer duration and offer effective protection for longer time. It is effective on tick, flea and lice in dogs and cats.


Composition:
  • Each mL contains :
    • Fipronil : 0.25% w/v
    • Excipients : q. s.
PHARMACOLOGY :
  • Mechanism of Action:Fipronil is a new generation broad-spectrum ectoparasiticide belonging to phenylpyrazole class. Fipronil disrupts the insect's central nervous system by blocking the passage of chloride ions through the GABA receptor and glutamate receptor (GluCl). Fipronil acts by binding to an allosteric site of GABA receptors. Its neurotoxicity is selective, because the configuration of GABA receptors in mammals is different from insects.
INDICATIONS :
  • Fipronil spray is used for effective treatment and prevention of all life stages of ectoparasites like tick (including ticks responsible for tick fever), flea (flea allergy dermatitis) and lice in Dogs and Cats.
DOSAGE AND ADMINISTRATION :
  • Each trigger application of spray delivers 0.5 mL spray volume.
Direction for Use :
  • Hold the bottle in upright position. Ruffle the animal’s coat while applying spray mist to its body. In order to wet the coat down to the skin the following application rates are recommended for use:
  • For Short-haired animals (< 1.5cm) - A minimum of 3mL/Kg body weight (7.5mg of active material per Kg of body weight) i.e. 6 pump actions per Kg.
    • Example :
    • For dogs under 12 Kg weight = 72 Pump actions
    • For dogs with 15 Kg weight = 90 Pump actions
    • For dogs with 30 Kg weight = 180 Pump actions
  • For Long-haired animals (> 1.5cm) - A minimum of 6mL/Kg body weight (15mg of active material per Kg of body weight) i.e. 12 pump actions per Kg.
    • Example :
    • For dogs under 12 Kg weight = 144 Pump actions
    • For dogs with 15 Kg weight = 180 Pump actions
    • For dogs with 30 Kg weight = 360 Pump actions
RESIDUAL ACTION:
  • Ticks : 1 month (3-5 week),
  • Fleas : 2 months (1-3 months)
  • This will depend on the parasite challenge in the animal's environment.
PRECAUTIONS :
  • Wear gloves during spraying.
  • Avoid spraying into eyes while spraying on face. To prevent spraying into eyes and to ensure proper coverage on head in nervous animals, puppies and kittens spray the solution onto the gloves first and then rub on face and other body parts of the pet.
  • Do not allow animal to lick the spray.
  • Do not bath or shampoo the animal for at least 2 days after Fipronil spray treatment.
  • Do not smoke, eat or drink during application.
  • Wash the hands after use.
  • Spray in well-ventilated area.
  • Keep sprayed animals away from source of heat until animal gets dry.
  • Do not spray directly on the area of damaged skin.
  • Do not apply to puppies & kittens below the age of eight weeks.
SAFETY :
  • Fipronil spray is safe to use in dogs and cats with no toxic effects when used in recommended way. Fipronil spray is not absorbed by skin and stay on for longer duration to provide effective protection.
  • Fipronil spray is safe to use on puppies and kittens over 8 weeks of age, adult cats and dogs,pregnant and lactating bitches.
TOXICITY :
  • In case of accidental ingestion or excessive licking by the pet contact the veterinarian immediately for symptomatic treatment. In case of contact with eyes or open wound, wash with plenty of fresh water immediately.
  • Note : Only for use by or under the control of a veterinarian.
PHYSICAL OR CHEMICAL HAZARDS :
  • Flammable Keep away from heat and open flame.
PRESENTATION :
  • Spray Bottle of 100 mL
STORAGE :
  • Store below 30℃ in dark place. Protect from heat and direct sunlight. Keep the container tightly closed.
  • Note : KEEP OUT OF REACH OF CHILDREN.
CONTAINER DISPOSAL :
  • Empty container or unused product can be disposed at waste disposal facility.
  • Do not reuse the container.

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Fipronil Spot On Solution For Cats & Kittens (0.5 mL)

The Fipronil Spot-on Solution For Cats & Kittens belongs to the family of phenylpyrazole and comes under the category of Insecticide-acaricide. It serves as the spot on control and treatment of Flea Allergy Dermatitis in cats and kittens.


Composition:
  • Each pipette Contains :
    • Fipronil : 9.8% w/w
    • S-Methoprene : 8.8% w/w
    • Excipients : q. s.
CATEGORY :
  • Insecticide-acaricide
PHARMACODYNAMICS :
  • Fipronil is belonging to the family phenylpyrazole. It acts by interaction with complexes formed between the chloride channels and their ligands, especially the neurotransmitter GABA (gamma-amino butyric acid), thus blocking the transfer of chloride ions across cell membranes to levels pre and post synaptic. It thus causes uncontrolled activity on the central nervous system of insects and mites and causes their death. Fipronil kills fleas within 24 hours, ticks (Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava and Haemaphysalis campanulata) and lice within 48 hours after application of the product.
    The S-Methoprene is a regulator of insect growth (ROI) of the class of similar juvenile hormone, it inhibits the development of immature stages of insects. Mimicking the action of the juvenile hormone, the compound causes impaired development and death of immature stages of fleas. The ovicidal activity of S-Methoprene applied to the cat results either from direct penetration into the shell flea eggs newly laid or its absorption through the cuticle of adult fleas. The S-Methoprene is also effective in preventing the development of larvae and pupae chip, prevents contamination of the habitat of cats treated with the immature stages of fleas.
PHARMACOKINETICS :
  • Pharmacokinetic studies have been reported for topical administration of Fipronil and S-Methoprene in association, in cats in comparison with those of each active ingredient administered separately intravenously. In cats, after administration of the association topically with oral exposure potential by licking, Fipronil has an absolute bioavailability (18%) with a mean plasma concentration maximum of approximately 100 ng/mL for Fipronil and 13 ng/mL for Fipronil sulfone. In cats, the plasma concentrations of Fipronil rapidly reach a peak average of about 6 hours and decreases with a half-life by approximately 25 hours. Fipronil is poorly metabolized by Fipronil sulfone in cats. Fipronil and its main metabolite and the SMethoprene spread widely in the cat's coat the day after application.
  • Plasma concentrations of S-Methoprene are generally below the quantification (20 ng/mL) in cats after topical administration.
  • The concentrations of Fipronil, Fipronil sulfone and S-Methoprene in peeling decrease with time, but are detectable at least 59 days after application in cats.
  • Parasites are killed mainly by contact and not by systemic exposure. No pharmacological interference between Fipronil and S-Methoprene was detected.
INDICATION AND DOSAGE :
  • Fipronil S-Methoprene Spot-On Solution provides fast, effective and convenient treatment and control of fleas, ticks and chewing lice. Treatment and prevention of flea infestation (CtenocephaIides spp) and biting lice (Trichodectes canis) in cats and kittens of 8 weeks or older.
  • Fipronil S-Methoprene Spot-On Solution has a rapid onset of action and kills re-infections with newly acquired adult fleas for at least one month.
  • Fipronil S-Methoprene Spot-On Solution also prevents the development of flea eggs, larvae and pupae produced by adult fleas acquired for six weeks after treatment.
  • Fipronil S-Methoprene Spot-On Solution may be used for the treatment and control of Flea Allergy Dermatitis in cats.
  • Fipronil S-Methoprene Spot-On Solution is used for flea control as it breaks the life cycle on the cat and in its surrounding by killing all stages of fleas.
Recommended Dosage for Cats & Kittens 8 weeks or older :
  • 0.5mL/pipette
TREATMENT FREQUENCY :
  • For Fleas : Monthly application is recommended for cats. All cats in a household should be treated at the same time. It is especially important to treat all household cats if any pet is allergic to fleas (flea allergy dermatitis).
  • Paralysis Ticks :Once monthly application in cat is recommended.
  • Biting Lice :Treat all household cats at the same time.
APPLICATION :
  • Break the snap-off top from the pipette along the scored line. Part the hair at back of cat, at the base of the neck between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze gently at one or two spots to empty its contents onto the skin. Care should be taken to avoid excessive wetting of hair during treatment of cats. Do not allow treated cats to lick each other or rub against other animals until the application site is completely dry.
CAUTION :
  • Hazardous to Human.
  • Fipronil S-Methoprene Spot-On Solution may cause irritation of mucous membranes, skin and eyes. So avoid contact of the product with the mouth, skin or eyes. Cats or those who have known hypersensitivity to insecticides or alcohol should avoid contact with the drug. Avoid contact of contents with the fingers. If this occurs, wash hands with soap and water. In case of accidental exposure with eyes, rinse with clean water carefully. Do not handle treated cats and don’t allow children to play with treated cats until the application site is completely dry. It is therefore recommended that cats are not treated in the day but in the early evening and that recently treated cats are not allowed to sleep with owners, especially children.
  • Do not smoke, drink or eat during application of Fipronil S-Methoprene Spot-On Solution.
  • Do not apply Fipronil S-Methoprene Spot-On Solution for more than 30 days.
SAFETY IN CATS :
  • For external use only.
  • Fipronil S-Methoprene Spot-On Solution is safe for use in cats and kittens over 8 weeks of age and in breeding, pregnant or lactating queens.
  • Do not use Fipronil S-Methoprene Spot-On Solution if you or your pet has a known hypersensitivity to insecticides or alcohol.
STORAGE :
  • Store below 30°C in dark place. Protect from heat and direct sunlight.
PHYSICAL OR CHEMICAL HAZARDS :
  • Flammable Keep away from heat and open flame
CONTAINER DISPOSAL:
  • Fipronil and S-Methoprene may adversely affect aquatic organisms.
  • Do not discard the product or empty pipettes in ponds, rivers and streams. Securely wrap pipette in several layers of newspaper and discard in trash.
  • Veterinary Product.
  • Not for human use.
  • For animal treatment only.
  • For external application only.
  • Note : FOR THE TREATMENT OF CATS ONLY.
PRESENTATION :
  • Fipronil S-Methoprene Spot-On Solution For Cats and Kittens From 8 Weeks Of Age - 3 Pipettes of 0.5 mL

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Fipronil Spot On For Puppies & Dogs

The Fipronil Spot-on Solution For Puppies & Dogs provides fast and effective of fleas, ticks and chewing lice. It works rapidly and kills re-infection. The spray breaks the development life cycle and kills all the stages of fleas, ticks and lice.


Fipronil Spot On For Puppies & Dogs
(upto 10 Kg Weight - 0.67 mL)

Fipronil Spot On For Dogs
(10 -20 Kg Weight – 1.34 mL)

Fipronil Spot On For Dogs
(20 -40 Kg Weight – 2.68 mL)

Fipronil Spot On For Dogs
(Over 40 Kg Weight - 4.02 mL)


Composition:
  • Each Pipette Contains:
    • Fipronil : 9.8% w/w
    • S-Methoprene : 8.8% w/w
    • Excipients : q. s.
CATEGORY :
  • Ectoparasiticide
PHARMACODYNAMICS :
  • Fipronil is belonging to the family phenylpyrazole. It acts by interaction with complexes formed between the chloride channels and their ligands, especially the neurotransmitter GABA (gamma-amino butyric acid), thus blocking the transfer of chloride ions across cell membranes to levels pre and post synaptic. It thus causes uncontrolled activity on the central nervous system of insects and mites and causes their death. Fipronil kills fleas within 24 hours, ticks (Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava and Haemaphysalis campanulata) and lice within 48 hours after application of the product. S-Methoprene is a regulator of insect growth (ROI) of the class of similar juvenile hormone which inhibits the development of immature stages of insects. Mimicking the action of the juvenile hormone, the compound causes impaired development and death of immature stages of fleas. The ovicidal activity of S-Methoprene applied to the dog results either from direct penetration into the shell flea eggs newly laid or its absorption through the cuticle of adult fleas. The S-Methoprene is also effective in preventing the development of larvae and pupae chip, prevents contamination of the habitat of dogs treated with the immature stages of fleas.
PHARMACOKINETICS :
  • Studies showed that absolute bioavailability of Fipronil was 9.5%. The Cmax was found to be 19 ng/mL in plasma found after 5 days (Tmax). Plasma concentrations were below 1ng/mL (limit of quantification) by maximum approximately 33 days following topical administration. S-Methoprene showed very low dermal absorption and all plasma concentrations were below the limit of quantification (10ng/mL).
  • In Dogs, Fipronil’s major metabolite on the haircoat of the dog and in the blood stream is the sulfone derivative. Fipronil sulfone is produced on the haircoat (mean concentrations < 16% of Fpronil during the first month after treatment). S-Methoprene is extensively degraded into carbon dioxide and acetate that are subsequently incorporated into endogenous materials.
  • In dogs after administration of the association topically, Fipronil is poorly absorbed (11%) with average maximum plasma concentration of approximately 35ng/mL for Fipronil and 55ng/mL for Fipronil sulfone.
  • In dogs, the plasma Fipronil concentrations slowly reached a peak average about 101 hours and decreasing slowly (half-life) by approximately 154 hours, the highest values are observed in males. Plasma concentrations of S-Methoprene are generally below the quantification (20ng/mL) in dogs after topical administration.
  • The concentrations of Fipronil, Fipronil sulfone and S-Methoprene in peeling decrease with time, but are detectable for at least 60 days after application in dogs.
  • Parasites are killed mainly by contact and not by systemic exposure. No pharmacological interference between Fipronil and s-Methoprene was detected.
INDICATION AND DOSAGE :
  • Fipronil S-Methoprene Spot-On provides fast, effective and convenient treatment and control of fleas, ticks and chewing lice. For treatment and prevention of flea infestation (Ctenocephalides spp.) and control of brown dog ticks (Rhipicephalus sanguineus), paralysis tick (Ixodes holocyclus) and biting lice (Trichodectes canis) on dogs. Fipronil S-Methoprene Spot-On has a rapid onset of action and kills re-infections with newly acquired adult fleas for at least one month.
  • Fipronil S-Methoprene Spot-On also prevents the development of flea eggs, larvae and pupae produced by adult fleas acquired for three months in dogs after treatment.
  • Fipronil S-Methoprene Spot-On controls brown dog ticks for up to one month and paralysis ticks for up to two weeks after application in dogs. Daily searching of dog is necessary to minimize the risk of tick paralysis. Searching should continue throughout the paralysis tick season.
  • Fipronil S-Methoprene Spot-On may be used for the treatment and control of Flea Allergy Dermatitis in dogs.
  • Fipronil S-Methoprene Spot-On is used for flea control as it breaks the life cycle on the dog and in its surrounding by killing all stages of fleas.
Dosage :
Recommended Dosage for Dogs Weight Spot-On Dose
Fipronil S-Methoprene Spot-On for small dogs (For use on puppies from 8 weeks of age) upto 10 Kg 0.67 mL/pipette
Fipronil S-Methoprene Spot-On for medium dogs 10 - 20 Kg 1.34 mL/pipette
Fipronil S-Methoprene Spot-On for large dogs 20 - 40 Kg 2.68 mL/pipette
Fipronil S-Methoprene Spot-On for extra-large dogs Over 40 Kg 4.02 mL/pipette
TREATMENT FREQUENCY :
  • For Fleas : Monthly application of Fipronil S-Methoprene Spot-On is recommended for dogs. All dogs in a household should be treated at the same time. It is especially important to treat all household dogs if any pet is allergic to fleas (flea allergy dermatitis).
  • Paralysis Ticks : Two-weekly application of Fipronil S-Methoprene Spot-On in dogs is recommended. It provides control of paralysis ticks for up to 2 weeks, use of this product does not guarantee prevention of tick paralysis because ticks are not killed immediately after attachment. Daily searching of dogs is necessary to minimize the risk of tick paralysis. Searching should continue throughout the paralysis tick season, which extends from spring to autumn, but may be year round in some localized areas.
  • Brown Dog Tick : Monthly application of Fipronil S-Methoprene Spot-On is recommended in dogs.
  • Biting Lice : Treat all household dogs at the same time with Fipronil S-Methoprene Spot-On.
APPLICATION :
  • Break the snap-off top from the pipette along the scored line. Part the hair at back of dog, at the base of the neck between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze gently at one or two spots to empty its contents onto the skin. Care should be taken to avoid excessive wetting of hair during treatment of dogs. Do not allow treated dogs to lick each other or rub against other animals until the application site is completely dry.
CAUTION :
  • Hazardous to Human.
  • Fipronil S-Methoprene Spot-On may cause irritation of mucous membranes, skin and eyes. So avoid contact of the product with the mouth, skin or eyes. Dogs or those who have known hypersensitivity to insecticides or alcohol should avoid contact with the drug. Avoid contact of contents with the fingers. If this occurs, wash hands with soap and water. In case of accidental exposure with eyes, rinse with clean water carefully. Do not handle treated dogs and don’t allow children to play with treated dogs until the application site is completely dry. It is therefore recommended that dogs are not treated in the day but in the early evening and that recently treated dogs are not allowed to sleep with owners, especially children. Do not smoke, drink or eat during application of Fipronil S-Methoprene Spot-On. Do not apply Fipronil S-Methoprene Spot-On for more than 30 days.
SAFETY IN DOGS :
  • For external use only.
  • Fipronil S-Methoprene Spot-On is safe for use in dogs and puppies over 8 weeks of age and in breeding, pregnant or lactating bitches.
  • Do not use Fipronil S-Methoprene Spot-On if you or your pet has a known hypersensitivity to insecticides or alcohol.
STORAGE :
  • Store below 30°C in dark place. Protect from heat and direct sunlight.
PHYSICAL OR CHEMICAL HAZARDS :
  • FLAMMABLE Keep away from heat and open flame.
CONTAINER DISPOSAL :
  • Fipronil and S-Methoprene may adversely affect aquatic organisms.
  • Do not discard the product or empty pipettes in ponds, rivers and streams. Securely wrap pipette in several layers of newspaper and discard in trash.
  • Veterinary Product.
  • Not for human use.
  • For animal treatment only.
  • For external application only.
  • Note :FOR THE TREATMENT OF DOGS ONLY.
PRESENTATION :
  • Fipronil S-Methoprene Spot-On For Dogs upto 10 kg - 3 Pipettes of 0.67 mL (For Use On Puppies From 8 Weeks Of Age)
  • Fipronil S-Methoprene Spot-On For Dogs over 10 kg upto 20 kg - 3 Pipettes of 1.34 mL
  • Fipronil S-Methoprene Spot-On For Dogs over 20 kg upto 40 kg - 3 Pipettes of 2.68 mL
  • Fipronil S-Methoprene Spot-On For Dogs over 40 kg - 3 Pipettes of 4.02 mL

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Bithionol Sulfoxide Bolus 2g

Bithionol Sulfoxide is an active anthelmintic for the treatment of fascioliosis and paramphistomosis, and has good activity against adult Oesophagostomum and some cestodes (Thysaniezia, Moniezia). It is also acting as an intestinal disinfectant. It can be administered in pregnant and lactating females without any change of feeding.


Composition:
  • Each Bolus of 2.7g Contains :
    • Bithionol Sulfoxide : 2.0 g
    • Excipients : q. s.
TARGET SPECIES :
  • Cattle, sheep, goats, dogs, cats, and poultry animals
ROUT OF ADMINISTRATION :
  • Oral
INDICATIONS :
  • Bithionol indicated for the effective treatment and control of liver fluke (Fasciola hepatica), Oesophagostomum, Paramphistomum, Tapeworms (Moniezia), Thysaniezia ovilla in cattle, sheep and goats.
MECHANISM OF ACTION :
  • Bithionol interferes with the neuromuscular physiology of helminths /(the target species)/, impairs egg formation, and may cause the protective cuticle covering the worms to become defective. At the biochemical level, oxidative phosphorylation is inhibited, and the bithionol molecule can chelate iron so that it may inactivate iron-containing enzyme systems.
CONTRAINDICATIONS :
  • Preferably not to be administered to animals which have not been vaccinated against enterotoxaemia.
INCOMPATIBILITY WITH OTHER DRUGS OR SUBSTANCES :
  • Do not combine with other anthelmintics.
DOSAGE AND ADMINISTRATION :
  • For oral administration.
  • General Dose - Bithionol Sulfoxide 60mg/Kg
  • Dog, Cat, Sheep, Goat : 200mg/kg
  • Quail : 200mg/kg Single dose
  • Chicken : 200mg/kg Twice within 4 days
  • Fowl, Goose : 600mg/kg as Single treatment.
  • Repeat treatment only on advice of your veterinarian.
WITHDRAWAL PERIOD :
  • Meat : 15 days
  • Milk : None
SIDE EFFECTS :
  • Mild and transitory diarrhoea may sometimes be observed.
PRESENTATION :
  • White coloured, 100 boli packed in HDPE jar along with pack insert.
STORAGE :
  • Store in well closed light resistant container in a cool and dry place below 30 C.

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